Article

p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells

2026-07-23

Abstract excerpt

Age is a principal risk factor for chronic respiratory diseases. During aging, the airway epithelium undergoes structural and functional changes, including a reduced regenerative capacity. Basal cells act as stem/progenitor cells within the airway epithelium and are known to acquire age-dependent intrinsic defects, such as genomic mutations, transcriptomic changes and declining stem cell potential. However, the mo...

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Literature Corpus work: ab54e0ec-e8d4-56ac-8ea1-fca5edc94457
DOI: 10.64898/2026.07.22.740085

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