Article
Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity.
Respiratory research - 3 Dec 2013
Walters Matthew S, Gomi Kazunori, Ashbridge Beth, Moore Malcolm A S, Arbelaez Vanessa, Heldrich Jonna, Ding Bi-Sen, Rafii Shahin, Staudt Michelle R, Crystal Ronald G
Abstract excerpt
BACKGROUND: As the multipotent progenitor population of the airway epithelium, human airway basal cells (BC) replenish the specialized differentiated cell populations of the mucociliated airway epithelium during physiological turnover and repair. Cultured primary BC divide a limited number of times before entering a state of replicative senescence, preventing the establishment of long-term replicating cultures of...
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