Article
Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy.
Circulation research - 28 Mar 2014
Eom Gwang Hyeon, Nam Yoon Seok, Oh Jae Gyun, Choe Nakwon, Min Hyun-Ki, Yoo Eun-Kyung, Kang Gaeun, Nguyen Vu Hong, Min Jung-Joon, Kim Jong-Keun, Lee In-Kyu, Bassel-Duby Rhonda, Olson Eric N, Park Woo Jin, Kook Hyun
Abstract excerpt
RATIONALE: Histone deacetylases (HDACs) are closely involved in cardiac reprogramming. Although the functional roles of class I and class IIa HDACs are well established, the significance of interclass crosstalk in the development of cardiac hypertrophy remains unclear. OBJECTIVE: Recently, we suggested that casein kinase 2α1-dependent phosphorylation of HDAC2 leads to enzymatic activation, which in turn induces...
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