Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy.

Cell - 23 Aug 2002

Zhang Chun Li, McKinsey Timothy A, Chang Shurong, Antos Christopher L, Hill Joseph A, Olson Eric N

Abstract excerpt

The heart responds to stress signals by hypertrophic growth, which is accompanied by activation of the MEF2 transcription factor and reprogramming of cardiac gene expression. We show here that class II histone deacetylases (HDACs), which repress MEF2 activity, are substrates for a stress-responsi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to Cardiomegaly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to Phosphotransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 12202037
DOI: 10.1016/s0092-8674(02)00861-9
PMCID: PMC4459650

Genes

HDAC9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12202037-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy.PMID 12202037Read ↗

Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac HypertrophySemantic proximity Read ↗

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.Semantic proximity Read ↗

Requirement of protein kinase D1 for pathological cardiac remodelingSemantic proximity Read ↗

The MEF2D transcription factor mediates stress-dependent cardiac remodeling in miceSemantic proximity Read ↗

Targeting histone deacetylase in cardiac diseasesSemantic proximity Read ↗

The black sheep of class IIa: HDAC7 SIKens the heartSemantic proximity Read ↗

Roles of histone acetylation sites in cardiac hypertrophy and heart failureSemantic proximity Read ↗

Chromatin modifications remodel cardiac gene expressionSemantic proximity Read ↗

Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy.Semantic proximity Read ↗

Recent discoveries of the role of histone modifications and related inhibitors in pathological cardiac hypertrophySemantic proximity Read ↗

Myocardin Induces Cardiomyocyte HypertrophySemantic proximity Read ↗

β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.