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Article

β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.

Journal of the American Heart Association - 25 Mar 2017

Weeks Kate L, Ranieri Antonella, Karaś Agnieszka, Bernardo Bianca C, Ashcroft Alexandra S, Molenaar Chris, McMullen Julie R, Avkiran Metin

Abstract excerpt

BACKGROUND: Class IIa histone deacetylase (HDAC) isoforms such as HDAC5 are critical signal-responsive repressors of maladaptive cardiomyocyte hypertrophy, through nuclear interactions with transcription factors including myocyte enhancer factor-2. β-Adrenoceptor (β-AR) stimulation, a signal of fundamental importance in regulating cardiac function, has been proposed to induce both phosphorylation-independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28343149
DOI: 10.1161/JAHA.116.004861
PMCID: PMC5533001

Genes

HDAC5

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β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.PMID 28343149Read ↗

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