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Article

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.

Nucleic acids research - 1 Sept 2013

Awad Salma, Kunhi Muhammad, Little Gillian H, Bai Yan, An Woojin, Bers Donald, Kedes Larry, Poizat Coralie

Abstract excerpt

Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that nuclear CaMKII activates cardiac transcrip...

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
Share to Cell Enlargement
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

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Share to Myocytes, Cardiac

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Source

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Identifiers

PMID: 23804765
DOI: 10.1093/nar/gkt500
PMCID: PMC3763528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23804765-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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