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Article

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.

Molecular and cellular biology - 1 Oct 2004

Chang Shurong, McKinsey Timothy A, Zhang Chun Li, Richardson James A, Hill Joseph A, Olson Eric N

Abstract excerpt

The adult heart responds to stress signals by hypertrophic growth, which is often accompanied by activation of a fetal cardiac gene program and eventual cardiac demise. We showed previously that histone deacetylase 9 (HDAC9) acts as a suppressor of cardiac hypertrophy and that mice lacking HDAC9...

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Identifiers

PMID: 15367668
DOI: 10.1128/MCB.24.19.8467-8476.2004
PMCID: PMC516756

Genes

HDAC9
HDAC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15367668-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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