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Article

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.

HPB : the official journal of the International Hepato Pancreato Biliary Association - 1 Oct 2012

Matthaei Hanno, Wu Jian, Dal Molin Marco, Debeljak Marija, Lingohr Philipp, Katabi Nora, Klimstra David S, Adsay N Volkan, Eshleman James R, Schulick Richard D, Kinzler Kenneth W, Vogelstein Bert, Hruban Ralph H, Maitra Anirban

Abstract excerpt

BACKGROUND: Activating point mutations of GNAS at codon 201 have been detected in approximately two thirds of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. Intraductal papillary neoplasms of the bile ducts (IPNBs) morphologically resemble pancreatic IPMNs. This study sought to...

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Share to Adenocarcinoma, Papillary
Share to Bile Duct Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Ducts, Intrahepatic

Share to Chromogranins

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Neoplasm Invasiveness

Share to Proto-Oncogene Proteins p21(ras)

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Source

Open in PubMed Open full text

Identifiers

PMID: 22954004
DOI: 10.1111/j.1477-2574.2012.00504.x
PMCID: PMC3461374

Genes

GNAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22954004-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.PMID 22954004Read ↗

GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".Semantic proximity Read ↗

GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct.Semantic proximity Read ↗

GNAS Is frequently mutated in a specific subgroup of intraductal papillary neoplasms of the bile duct.Semantic proximity Read ↗

Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas.Semantic proximity Read ↗

Intraductal oncocytic papillary neoplasm arising in Peutz-Jeghers Syndrome bile duct: a unique case report.Semantic proximity Read ↗

Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.Semantic proximity Read ↗

GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.Semantic proximity Read ↗

Neoplastic Progression in Intraductal Papillary Neoplasm of the Bile Duct.Semantic proximity Read ↗

Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma.Semantic proximity Read ↗

Tumoral Intraductal Neoplasms of the Bile Ducts Comprise Morphologically and Genetically Distinct EntitiesSemantic proximity Read ↗

Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts.Semantic proximity Read ↗

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