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Article

Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas.

Annals of surgical oncology - 1 Nov 2013

Molin Marco Dal, Matthaei Hanno, Wu Jian, Blackford Amanda, Debeljak Marija, Rezaee Neda, Wolfgang Christopher L, Butturini Giovanni, Salvia Roberto, Bassi Claudio, Goggins Michael G, Kinzler Kenneth W, Vogelstein Bert, Eshleman James R, Hruban Ralph H, Maitra Anirban

Abstract excerpt

BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are the most common cystic precursor lesions of invasive pancreatic cancer. The recent identification of activating GNAS mutations at codon 201 in IPMNs is a promising target for early detection and therapy. The purpose of this study was to explore clinicopathological correlates of GNAS mutational status in resected IPMNs. METHODS: Clinical and...

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Share to Adenocarcinoma, Mucinous
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Papillary

Share to Chromogranins

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Pancreas

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Source

Open in PubMed Open full text

Identifiers

PMID: 23846778
DOI: 10.1245/s10434-013-3096-1
PMCID: PMC3842009

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas.PMID 23846778Read ↗

GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".Semantic proximity Read ↗

Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype.Semantic proximity Read ↗

GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma.Semantic proximity Read ↗

GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.Semantic proximity Read ↗

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.Semantic proximity Read ↗

Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation.Semantic proximity Read ↗

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

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Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas: current understanding and perspectives on malignant progression.Semantic proximity Read ↗

Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.Semantic proximity Read ↗

Relevance of gene mutations and methylation to the growth of pancreatic intraductal papillary mucinous neoplasms based on pyrosequencing.Semantic proximity Read ↗

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