Article
Human leukaemic stem cells: a novel target of therapy.
European journal of clinical investigation - 1 Aug 2004
Sperr W R, Hauswirth A W, Florian S, Ohler L, Geissler K, Valent P
Abstract excerpt
Acute myeloid leukaemia (AML) is a life-threatening haematopoietic disease that is characterized by clonal growth and the accumulation of myelopoietic progenitor cells. Although AML cells only have a limited potential to undergo differentiation and maturation, each AML clone is organized in a hierarchical manner similar to normal haematopoiesis. Recent data have shown that each AML clone consists of leukaemic...
Topics
- Forecasting
- Gene Targeting
- Genetic Therapy
- Hematopoietic Stem Cells
- Humans
- Leukemia, Myeloid
- Neoplastic Stem Cells
- Phenotype