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Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia

6 Nov 2017

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow characterized by an uncontrolled proliferation of undifferentiated myeloid lineage cells. Decades of research have demonstrated that AML evolves from the sequential acquisition of genetic alterations within a single lineage of hematopoietic cells. More recently, the advent of high-throughput sequencing has enabled the identification of a...

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PMID: 29164062
DOI: 10.3389/fonc.2017.00263

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