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Article

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

Acta neuropathologica communications - 11 Feb 2014

George Sonia, Rönnbäck Annica, Gouras Gunnar K, Petit Géraldine H, Grueninger Fiona, Winblad Bengt, Graff Caroline, Brundin Patrik

Abstract excerpt

BACKGROUND: The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions,...

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Identifiers

PMID: 24517102
DOI: 10.1186/2051-5960-2-17
PMCID: PMC3932948

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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