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Article

Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Trujillo-Estrada Laura, Dávila José Carlos, Sánchez-Mejias Elisabeth, Sánchez-Varo Raquel, Gomez-Arboledas Angela, Vizuete Marisa, Vitorica Javier, Gutiérrez Antonia

Abstract excerpt

The progressive cognitive decline leading to dementia in Alzheimer's disease (AD) patients is the consequence of a severe loss of synapses and neurons affecting particular cell subpopulations in selected brain areas, with the subiculum being one of the earliest regions displaying severe atrophy and pathology. The lack of significant neuronal loss in most AD models is, in fact, the major shortcoming for the...

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PMID: 24927710
DOI: 10.3233/JAD-140495

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Source receipt: pubmed, retrieved 7 Sept 2026.

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