Article

Investigating Regional Specificity of Alzheimer’s Disease Pathology in the 5xFAD Mouse Model

2021-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a neurodegenerative disease that affects cognition and memory. Mouse models such as 5xFAD, incorporate mutations found in familial or early-onset (EOAD) AD; these mutations increase the production of the toxic AB species that contributes to plaque formation in the brain. However, not all brain regions in the 5xAD animals accumulate plaques to the same degree. For exam...

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Literature Corpus work: d9c9d6b5-8492-5455-a08b-8c656e68eda7
DOI: 10.1101/2021.07.08.441803

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