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Article

Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions.

Neurobiology of aging - 1 Apr 2012

Rönnbäck Annica, Sagelius Hanna, Bergstedt Karin Dillner, Näslund Jan, Westermark Gunilla T, Winblad Bengt, Graff Caroline

Abstract excerpt

The Arctic APP mutation (E693G) within the amyloid β (Aβ) domain of amyloid precursor protein (APP) leads to dementia with clinical features similar to Alzheimer's disease (AD), which is believed to be mediated via increased formation of protofibrils. We have generated a transgenic mouse model, TgAPParc, with neuron-specific expression of human amyloid precursor protein with the Arctic mutation (hAPParc), showing...

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Source

Identifiers

PMID: 21880397
DOI: 10.1016/j.neurobiolaging.2011.07.012

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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