Article

Aβ promotes amyloidogenic processing of APP through a Go/Gβγ signaling

2021-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is characterized by a cognitive impairment associated to amyloid beta (Aβ) aggregation and deposition in the brain. Aβ is generated by sequential cleavage of the amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase complex. The mechanisms that underlie exacerbated production of Aβ, favoring its deposition in the brain, is largely unknow...

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Literature Corpus work: e341b4fa-47cf-5be6-804b-4f6ef5b0e2f5
DOI: 10.1101/2021.03.10.434768

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