Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.

American journal of human genetics - 1 Jan 2007

Shi Min, Christensen Kaare, Weinberg Clarice R, Romitti Paul, Bathum Lise, Lozada Anthony, Morris Richard W, Lovett Michael, Murray Jeffrey C

Abstract excerpt

Maternal smoking is a recognized risk factor for orofacial clefts. Maternal or fetal pharmacogenetic variants are plausible modulators of this risk. In this work, we studied 5,427 DNA samples, including 1,244 from subjects in Denmark and Iowa with facial clefting and 4,183 from parents, siblings, or unrelated population controls. We examined 25 single-nucleotide polymorphisms in 16 genes in pathways for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Cleft Lip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cleft Palate

Share to Cytochrome P-450 CYP1A1

Share to Embryo, Mammalian

Share to Glutathione Transferase

Share to History, 16th Century

Share to Maternal Exposure

Source

Open in PubMed Open full text

Identifiers

PMID: 17160896
DOI: 10.1086/510518
PMCID: PMC1785306

Genes

GSTT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.PMID 17160896Read ↗

Maternal smoking and oral clefts: the role of detoxification pathway genes.Semantic proximity Read ↗

Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms.Semantic proximity Read ↗

Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction.Semantic proximity Read ↗

Maternal smoking, genetic variation of glutathione s-transferases, and risk for orofacial clefts.Semantic proximity Read ↗

Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects.Semantic proximity Read ↗

Unraveling human cleft lip and palate research.Semantic proximity Read ↗

The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility.Semantic proximity Read ↗

The genetics and epigenetics of orofacial clefts.Semantic proximity Read ↗

Secondary Genome-Wide Association Study Using Novel Analytical Strategies Disentangle Genetic Components of Cleft Lip and/or Cleft Palate in 1q32.2.Semantic proximity Read ↗

Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleft.Semantic proximity Read ↗

Fetal lung and placental methylation is associated with in utero nicotine exposureSemantic proximity Read ↗

Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during PregnancySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.