Article
Gene-gene interaction between MSX1 and TP63 in Asian case-parent trios with nonsyndromic cleft lip with or without cleft palate.
Birth defects research - 1 Mar 2018
Liu Dongjing, Schwender Holger, Wang Mengying, Wang Hong, Wang Ping, Zhu Hongping, Zhou Zhibo, Li Jing, Wu Tao, Beaty Terri H
Abstract excerpt
BACKGROUND: Small ubiquitin-like modification, also known as sumoylation, is a crucial post-translational regulatory mechanisms involved in development of the lip and palate. Recent studies reported two sumoylation target genes, MSX1 and TP63, to have achieved genome-wide level significance in tests of association with nonsyndromic clefts. Here, we performed a candidate gene analysis considering gene-gene and...
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