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Article

TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.

The Journal of infectious diseases - 15 Jul 2014

Stappers Mark H T, Thys Yati, Oosting Marije, Plantinga Theo S, Ioana Mihai, Reimnitz Peter, Mouton Johan W, Netea Mihai G, Joosten Leo A B, Gyssens Inge C

Abstract excerpt

BACKGROUND: Complicated skin and skin structure infections (cSSSIs) are characterized by infections with gram-positive or gram-negative aerobic or anaerobic bacteria, as well as by a polymicrobial etiology. These invading microorganisms are recognized by pattern-recognition receptors (PRRs) of the innate immune system. This study assessed whether genetic variation in genes encoding PRRs influences the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Toll-Like Receptor 1

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Source

Identifiers

PMID: 24511099
DOI: 10.1093/infdis/jiu080

Genes

TLR1
TLR2
TLR6
TIRAP
NOD2
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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