Article
The impact of toll-like receptor polymorphisms on susceptibility to fungal infections: a systematic review of genetic and clinical data.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jul 2026
Staiger Martha Fabielle Pereira, Souza Gleyce Hellen de Almeida, Venturini James, Peres Nalu Teixeira de Aguiar, Lucini Fabíola, Santos Daniel Assis, Bastos Rafael Wesley, Carvalho Agostinho, Rossato Luana
Abstract excerpt
BACKGROUND: Fungal infections affect over 1.5 billion people, with invasive diseases posing a significant threat to immunocompromised individuals. Toll-like receptors (TLRs) are critical components of innate immunity. Single nucleotide polymorphisms (SNPs) in TLR genes are associated with altered immune responses to fungal infections. OBJECTIVES: To summarize and critically appraise the available evidence on TLR...
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