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Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Sept 2013

Medvedev Andrei E

Abstract excerpt

Toll-like receptors (TLRs) are germ-line-encoded innate immune sensors that recognize conserved microbial structures and host alarmins and signal expression of MHC proteins, costimulatory molecules, and inflammatory mediators by macrophages, neutrophils, dendritic cells, and other cell types. These processes activate immediate and early mechanisms of innate host defense, as well as initiate and orchestrate...

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Identifiers

PMID: 23675778
DOI: 10.1089/jir.2012.0140
PMCID: PMC3760066

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