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Article

Genetic Variation in TLR10, an Inhibitory Toll-Like Receptor, Influences Susceptibility to Complicated Skin and Skin Structure Infections.

The Journal of infectious diseases - 1 Nov 2015

Stappers Mark H T, Oosting Marije, Ioana Mihai, Reimnitz Peter, Mouton Johan W, Netea Mihai G, Gyssens Inge C, Joosten Leo A B

Abstract excerpt

BACKGROUND: Toll-like receptors (TLRs) play a central role in the innate immune response to complicated skin and skin structure infections (cSSSIs), with TLR10 being the first family member known to have an inhibitory function. This study assessed the role of TLR10 in recognition of cSSSI-related pathogens and whether genetic variation in TLR10 influences susceptibility to cSSSIs. METHODS: Human peripheral blood...

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Source

Identifiers

PMID: 25895985
DOI: 10.1093/infdis/jiv229

Genes

TLR10
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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