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Article

Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans.

Archivum immunologiae et therapiae experimentalis - 1 Dec 2013

Frazão Josias Brito, Errante Paolo Ruggero, Condino-Neto Antonio

Abstract excerpt

Toll-like receptors (TLRs) sense microbial products and play an important role in innate immunity. Currently, 11 members of TLRs have been identified in humans, with important function in host defense in early steps of the inflammatory response. TLRs are present in the plasma membrane (TLR1, TLR2, TLR4, TLR5, TLR6) and endosome (TLR3, TLR7, TLR8, TLR9) of leukocytes. TLRs and IL-1R are a family of receptors...

Topics

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Adaptor Proteins, Signal Transducing
Cytokines
Genetic Predisposition to Disease
Infections
Inflammation Mediators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Signal Transduction

Toll-Like Receptors

Source

Identifiers

PMID: 24057516
DOI: 10.1007/s00005-013-0243-0

Genes

TIRAP
TLR1
TLR2
TLR3
TLR4
TLR5
TLR6
TLR7
TLR8
TLR9
TNF

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