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Article

Generation and characterization of humanized mice carrying COMT158 Met/Val alleles.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2014

Risbrough Victoria, Ji Baohu, Hauger Richard, Zhou Xianjin

Abstract excerpt

The Val158Met polymorphism of human catechol-o-methyltransferase (COMT) is one of the most well-studied single-nucleotide polymorphisms in neuropsychiatry; however, findings are inconsistent due to human genetic heterogeneity. We created the first 'humanized' COMTVal158Met mouse lines, which carry either human COMT Val or Met alleles via gene targeting. The 'humanized' mouse model enables strict comparison of the...

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Identifiers

PMID: 24509724
DOI: 10.1038/npp.2014.29
PMCID: PMC4059890

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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