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Article

Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Aug 2008

Papaleo Francesco, Crawley Jacqueline N, Song Jian, Lipska Barbara K, Pickel Jim, Weinberger Daniel R, Chen Jingshan

Abstract excerpt

The COMT (catechol-O-methyltransferase) gene has been linked to a spectrum of human phenotypes, including cognition, anxiety, pain sensitivity and psychosis. Doubts about its clinical impact exist, however, because of the complexity of human COMT polymorphism and clinical variability. We generated transgenic mice overexpressing a human COMT-Val polymorphism (Val-tg), and compared them with mice containing a null...

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Source

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Identifiers

PMID: 18753372
DOI: 10.1523/JNEUROSCI.2077-08.2008
PMCID: PMC2561993

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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