Article
COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans.
Cerebral cortex (New York, N.Y. : 1991) - 1 Sept 2015
Sannino Sara, Gozzi Alessandro, Cerasa Antonio, Piras Fabrizio, Scheggia Diego, Managò Francesca, Damiano Mario, Galbusera Alberto, Erickson Lucy C, De Pietri Tonelli Davide, Bifone Angelo, Tsaftaris Sotirios A, Caltagirone Carlo, Weinberger Daniel R, Spalletta Gianfranco, Papaleo Francesco
Abstract excerpt
Genetic variations in catechol-O-methyltransferase (COMT) that modulate cortical dopamine have been associated with pleiotropic behavioral effects in humans and mice. Recent data suggest that some of these effects may vary among sexes. However, the specific brain substrates underlying COMT sexual dimorphisms remain unknown. Here, we report that genetically driven reduction in COMT enzyme activity increased...
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