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Article

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

Molecular psychiatry - 1 Apr 2018

Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca M A, Piomelli D, Parolaro D, Papaleo F

Abstract excerpt

The prefrontal cortex (PFC) is a crucial hub for the flexible modulation of recent memories (executive functions) as well as for the stable organization of remote memories. Dopamine in the PFC is implicated in both these processes and genetic variants affecting its neurotransmission might control the unique balance between cognitive stability and flexibility present in each individual. Functional genetic variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28630452
DOI: 10.1038/mp.2017.126

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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