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Article

Effects of sex and COMT genotype on environmentally modulated cognitive control in mice.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2012

Papaleo Francesco, Erickson Lucy, Liu Guangping, Chen Jingshan, Weinberger Daniel R

Abstract excerpt

Cognitive functioning differs between males and females, likely in part related to genetic dimorphisms. An example of a common genetic variation reported to have sexually dimorphic effects on cognition and temperament in humans is the Val/Met polymorphism in catechol-O-methyltransferase (COMT). We tested male and female wild-type mice ((+/+)) and their COMT knockout littermates ((+/-) and (-/-)) in the...

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Source

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Identifiers

PMID: 23169629
DOI: 10.1073/pnas.1214397109
PMCID: PMC3523843

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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