Article
Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2016
Barkus Chris, Korn Clio, Stumpenhorst Katharina, Laatikainen Linda M, Ballard Dominic, Lee Sheena, Sharp Trevor, Harrison Paul J, Bannerman David M, Weinberger Daniel R, Chen Jingshan, Tunbridge Elizabeth M
Abstract excerpt
Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex. The human gene contains a polymorphism (Val158Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but the findings are mixed. We therefore developed a novel mouse model of altered COMT activity. The human Met allele was introduced into the native mouse COMT gene to...
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