Article

Humanized substitutions of <i>Vmat1</i> in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

2021-05-19

Abstract excerpt

The human vesicular monoamine transporter 1 ( VMAT1 ) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles. These substitutions are absent in all known mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic transmission, such as emotion and cognition. To directly test the impact of these human-specific mutations, we intr...

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Literature Corpus work: bb852488-0ad9-549d-8658-0a17780e1545
DOI: 10.1101/2021.05.18.444749

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