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Article

Generation of membrane-bound catechol-O-methyl transferase deficient mice with disctinct sex dependent behavioral phenotype.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Dec 2016

Tammimaki A, Aonurm-Helm A, Zhang F P, Poutanen M, Duran-Torres G, Garcia-Horsman A, Mannisto P T

Abstract excerpt

Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-MT), anchored to intracellular membranes. COMT is involved in the O-methylation of L-DOPA, dopamine and other catechols. The exact role of MB-COMT is still mostly unclear. We wanted to create a novel genetically modified mouse model that specifically lacks MB-COMT activity and to study...

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Behavior, Animal
Catechol O-Methyltransferase
Dopamine
Intracellular Membranes
Levodopa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Memory, Short-Term

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PMID: 28195063

Genes

COMT

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