Article
Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Gogos J A, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M
Abstract excerpt
Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. By means...
Topics
- Amino Acid Sequence
- Animals
- Behavior, Animal
- Brain
- Catechol O-Methyltransferase
- Catecholamines
- Disease Models, Animal
- Female
- Heterozygote
- Homozygote
- Humans
- Male
- Mental Disorders
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Molecular Sequence Data
- Phenotype