Article
Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Gogos J A, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M
Abstract excerpt
Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. By means of homologous recombination in embryonic stem cells, a strain of mice in which the gene encoding the COMT enzyme has...
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