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Article

Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer.

Accounts of chemical research - 16 Jan 2018

Silva Jerson L, Cino Elio A, Soares Iaci N, Ferreira Vitor F, A P de Oliveira Guilherme

Abstract excerpt

Prion-like behavior of several amyloidogenic proteins has been demonstrated in recent years. Despite having functional roles in some cases, irregular aggregation can have devastating consequences. The most commonly known amyloid diseases are Alzheimer's, Parkinson's, and Transmissible Spongiform Encephalopathies (TSEs). The pathophysiology of prion-like diseases involves the structural transformation of wild-type...

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Source

Identifiers

PMID: 29260852
DOI: 10.1021/acs.accounts.7b00473

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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