Article
Prion-like aggregation of mutant p53 in cancer.
Trends in biochemical sciences - 1 Jun 2014
Silva Jerson L, De Moura Gallo Claudia V, Costa Danielly C F, Rangel Luciana P
Abstract excerpt
p53 is a master regulatory protein that participates in cellular processes such as apoptosis, DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and is lost in more than 50% of human cancers. Recent studies have suggested that the formation of mutant p53 aggregates is associated with loss-of-function (LoF), dominant-negative (DN), and gain-of-function (GoF) effects. We propose...
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