Article
Somatic mutations and epigenetic abnormalities in myelodysplastic syndromes.
Best practice & research. Clinical haematology - 1 Dec 2013
Itzykson Raphael, Kosmider Olivier, Fenaux Pierre
Abstract excerpt
During many years, very limited data had been available on specific gene mutations in MDS in particular due to the fact that balanced chromosomal translocations (which have allowed to discover many "leukemia" genes) are very rare in MDS, while chromosomal deletions are generally very large, making it difficult to identify genes of interest. Recently, the advent of next generation sequencing (NGS) techniques has...
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