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Article

Genome sequencing in the management of myelodysplastic syndromes and related disorders.

Haematologica - 1 Feb 2025

Cazzola Mario, Malcovati Luca

Abstract excerpt

Myeloid neoplasms originate from the clonal proliferation of hematopoietic stem cells, which is driven by the acquisition of somatic genetic mutations. Within these disorders, myelodysplastic syndromes (MDS) are specifically characterized by morphological abnormalities (dysplasia) and impaired maturation of myeloid precursors (ineffective hematopoiesis), resulting in peripheral blood cytopenia. Several studies...

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Identifiers

PMID: 39445412
DOI: 10.3324/haematol.2023.284947
PMCID: PMC11788631

Genes

SF3B1
TET2
TP53

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