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Article

Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth.

PloS one - 1 Jan 2014

Williams Richard T, Barnhill Lisa M, Kuo Huan-Hsien, Lin Wen-Der, Batova Ayse, Yu Alice L, Diccianni Mitchell B

Abstract excerpt

The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line. This mutation aligns the reading frames of p14ARF and p16 mid-transcript, producing one protein which is half p14ARF and half p16, chimera ARF (chARF), and another which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24505435
DOI: 10.1371/journal.pone.0088219
PMCID: PMC3914946

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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