Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6.

Cancer research - 1 Oct 2007

Jones Rebecca, Ruas Margarida, Gregory Fiona, Moulin Stephanie, Delia Domenico, Manoukian Siranoush, Rowe Janice, Brookes Sharon, Peters Gordon

Abstract excerpt

The CDKN2A locus encodes two distinct proteins, p16INK4a and p14ARF, both of which are implicated in replicative senescence and tumor suppression in different contexts. Here, we describe the characterization of a novel strain of human diploid fibroblasts (designated Milan HDFs) from an individual who is homozygous for the R24P mutation in p16INK4a. As this mutation occurs in the first exon of INK4a (exon 1alpha),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Growth Processes
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 4

Share to Cyclin-Dependent Kinase 6

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Diploidy

Share to Genes, p16

Share to Melanoma

Source

Identifiers

PMID: 17909018
DOI: 10.1158/0008-5472.CAN-07-1528

Genes

CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6.PMID 17909018Read ↗

Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding.Semantic proximity Read ↗

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.Semantic proximity Read ↗

Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF.Semantic proximity Read ↗

Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A.Semantic proximity Read ↗

Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression.Semantic proximity Read ↗

CDKN2A (p16INK4A) somatic and germline mutations.Semantic proximity Read ↗

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanomaSemantic proximity Read ↗

Functional, structural, and genetic evaluation of 20<i>CDKN2A</i>germ line mutations identified in melanoma-prone families or patientsSemantic proximity Read ↗

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts.Semantic proximity Read ↗

Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma.Semantic proximity Read ↗

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.Semantic proximity Read ↗

p16 proteins from melanoma-prone families are deficient in binding to Cdk4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.