End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.

doi:10.1002/art.38220

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Article

End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2014

Freedman Barry I, Langefeld Carl D, Andringa Kelly K, Croker Jennifer A, Williams Adrienne H, Garner Neva E, Birmingham Daniel J, Hebert Lee A, Hicks Pamela J, Segal Mark S, Edberg Jeffrey C, Brown Elizabeth E, Alarcón Graciela S, Costenbader Karen H, Comeau Mary E, Criswell Lindsey A, Harley John B, James Judith A, Kamen Diane L, Lim S Sam, Merrill Joan T, Sivils Kathy L, Niewold Timothy B, Patel Neha M, Petri Michelle, Ramsey-Goldman Rosalind, Reveille John D, Salmon Jane E, Tsao Betty P, Gibson Keisha L, Byers Joyce R, Vinnikova Anna K, Lea Janice P, Julian Bruce A, Kimberly Robert P

Abstract excerpt

OBJECTIVE: Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease (ESRD). LN is more prevalent among African Americans than among European Americans. This study was undertaken to investigate the hypothesis that the apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in African Americans...

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Identifiers

PMID: 24504811
DOI: 10.1002/art.38220
PMCID: PMC4002759

Genes

APOL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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