Article
Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.
Kidney international - 1 Sept 2018
Langefeld Carl D, Comeau Mary E, Ng Maggie C Y, Guan Meijian, Dimitrov Latchezar, Mudgal Poorva, Spainhour Mitzie H, Julian Bruce A, Edberg Jeffrey C, Croker Jennifer A, Divers Jasmin, Hicks Pamela J, Bowden Donald W, Chan Gary C, Ma Lijun, Palmer Nicholette D, Kimberly Robert P, Freedman Barry I
Abstract excerpt
African Americans carrying two apolipoprotein L1 gene (APOL1) renal risk variants have a high risk for nephropathy. However, only a minority develops end-stage renal disease (ESRD). Hence, modifying factors likely contribute to initiation of kidney disease such as endogenous (HIV infection) or exogenous (interferon treatment) environmental modifiers. In this report, genome-wide association studies and a...
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