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Article

APOL1 and the risk of adverse renal outcomes in patients of African ancestry with systemic lupus erythematosus.

Lupus - 1 May 2023

Chung Cecilia P, Karakoc Gul, Dickson Alyson, Liu Ge, Gamboa Jorge L, Mosley Jonathan D, Cox Nancy J, Kawai Vivian K

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) disproportionately affects individuals of African ancestry (AA) compared to European ancestry (EA). In the general population, high risk (HR) variants in the apolipoprotein L1 (APOL1) gene increase the risk of renal and hypertensive disorders in individuals of AA. Since SLE is characterized by an interferon signature and APOL1 expression is driven by interferon, we...

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Identifiers

PMID: 37105192
DOI: 10.1177/09612033231172660
PMCID: PMC10189827

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