Article
Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.
Aging cell - 1 Jun 2011
Kulminski Alexander M, Culminskaya Irina, Ukraintseva Svetlana V, Arbeev Konstantin G, Arbeeva Liubov, Wu Deqing, Akushevich Igor, Land Kenneth C, Yashin Anatoli I
Abstract excerpt
Progress in unraveling the genetic origins of healthy aging is tempered, in part, by a lack of replication of effects, which is often considered a signature of false-positive findings. We convincingly demonstrate that the lack of genetic effects on an aging-related trait can be because of trade-offs in the gene action. We focus on the well-studied apolipoprotein E (APOE) e2/3/4 polymorphism and on lifespan and...
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