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Article

HSC commitment–associated epigenetic signature is prognostic in acute myeloid leukemia

2 Feb 2014

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by disruption of HSC and progenitor cell differentiation. Frequently, AML is associated with mutations in genes encoding epigenetic modifiers. We hypothesized that analysis of alterations in DNA methylation patterns during healthy HSC commitment and differentiation would yield epigenetic signatures that could be used to identify stage-specific prognostic subgroups of...

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Share to Acute Myeloid Leukemia Research
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PMID: 24487588
DOI: 10.1172/jci71264

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