Article

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

2020-02-20

Abstract excerpt

In the current understanding of adult bone marrow hematopoiesis, megakaryocytes (MKs) originate from cells immuno-phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. Here, we use single cell RNA sequencing to characterize HSCs and MKs from human bone marrow, to investigate MK lineage commitment and maturation. We identify two MK primed HSC clusters exhibiting...

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Literature Corpus work: 0f504bc2-5065-5fa3-a2cb-e7725ae52135
DOI: 10.1101/2020.02.20.957936

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