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Quantitative DNA methylation predicts survival in adult acute myeloid leukemia

11 Nov 2009

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by molecular heterogeneity that is not fully reflected in the current classification system. Recent insights point toward a significant role of aberrant DNA methylation in leukemogenesis. Therefore, we investigated the prognostic impact of DNA methylation in AML. To screen for promoter methylation in AML we applied a combination of base-specific cleavage biochemistry...

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PMID: 19903898
DOI: 10.1182/blood-2009-03-211003

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