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Article

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

4 Jun 2008

Abstract excerpt

DNA methylation of CpG islands around gene transcription start sites results in gene silencing and plays a role in leukemia pathophysiology. Its impact in leukemia progression is not fully understood. We performed genomewide screening for methylated CpG islands and identified 8 genes frequently methylated in leukemia cell lines and in patients with acute myeloid leukemia (AML): NOR1, CDH13, p15, NPM2, OLIG2, PGR,...

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PMID: 18523155
DOI: 10.1182/blood-2007-11-126227

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