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Article

Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred.

Psychiatric genetics - 1 Oct 2017

Melhem Nadine M, Hamdan Sami, Klei Lambertus, Wood Shawn, Zelazny Jamie, Frisch Amos, Weizman Abraham, Carmel Miri, Michaelovsky Elena, Farbstein Ilana, Wasserman Danuta, El-Heib Muhammad, Ferrell Robert, Apter Alan, Devlin Bernie, Brent David

Abstract excerpt

OBJECTIVES: Inbreeding increases the probability of homozygosity of deleterious alleles. Inbreeding and runs of homozygosity (ROH) are associated with an increased risk for disease phenotypes, including schizophrenia and other psychiatric disorders. The effects of inbreeding, ROH, homozygous deletions, and other copy number variations (CNVs) on risk for depression and suicide attempt (SA) were quantified in an...

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Identifiers

PMID: 28570395
DOI: 10.1097/YPG.0000000000000177
PMCID: PMC5572483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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