Article
Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.
The Journal of clinical endocrinology and metabolism - 1 May 2009
Panicker Vijay, Saravanan Ponnusamy, Vaidya Bijay, Evans Jonathan, Hattersley Andrew T, Frayling Timothy M, Dayan Colin M
Abstract excerpt
INTRODUCTION: Animal studies suggest that up to 80% of intracellular T(3) in the brain is derived from circulating T(4) by local deiodination. We hypothesized that in patients on T(4) common variants in the deiodinase genes might influence baseline psychological well-being and any improvement on combined T(4)/T(3) without necessarily affecting serum thyroid hormone levels. METHODS: We analyzed common variants in...
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