Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of <i>PALB2</i> -Associated Hereditary Breast Cancer

Abstract excerpt

Abstract Hereditary breast cancers stem from germline mutations in susceptibility genes such as BRCA1, BRCA2, and PALB2, whose products function in the DNA damage response and redox regulation. Autophagy is an intracellular waste disposal and stress mitigation mechanism important for alleviating oxidative stress and DNA damage response activation; it can either suppress or promote cancer, but its role in breast...

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