Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy.

Scientific reports - 10 Sept 2020

Kumar Mukesh, Papaleo Elena

Abstract excerpt

Autophagy is a key clearance process to recycle damaged cellular components. One important upstream regulator of autophagy is ULK1 kinase. Several three-dimensional structures of the ULK1 catalytic domain are available, but a comprehensive study, including molecular dynamics, is missing. Also, an exhaustive description of ULK1 alterations found in cancer samples is presently lacking. We here applied a framework...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Intracellular Signaling Peptides and Proteins
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Phosphorylation

Share to Signal Transduction

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 32913252
DOI: 10.1038/s41598-020-71527-4
PMCID: PMC7483646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy.PMID 32913252Read ↗

The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer.Semantic proximity Read ↗

The conformational and mutational landscape of the ubiquitin-like marker for the autophagosome formation in cancerSemantic proximity Read ↗

Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach.Semantic proximity Read ↗

ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteinsSemantic proximity Read ↗

ULK1 and ULK2 are less redundant than previously thought: Computational analysis uncovers distinct regulation and functions of these autophagy induction proteinsSemantic proximity Read ↗

Model-based analysis uncovers mutations altering autophagy selectivity in human cancer.Semantic proximity Read ↗

Decoding ATG9A Variation: A Comprehensive Structural Investigation of All Missense VariantsSemantic proximity Read ↗

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent InhibitorsSemantic proximity Read ↗

Unraveling the mysterious veil of ULK1: From non-canonical functions to therapeutic applicationsSemantic proximity Read ↗

Sequence and structure signatures of cancer mutation hotspots in protein kinases.Semantic proximity Read ↗

Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancerSemantic proximity Read ↗

Structure and function of the ULK1 complex in autophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.